Stratifin (14-3-3 σ) Limits Plakophilin-3 Exchange with the Desmosomal Plaque
نویسندگان
چکیده
منابع مشابه
Stratifin (14-3-3 σ) Limits Plakophilin-3 Exchange with the Desmosomal Plaque
Desmosomes are prominent cell-cell adhesive junctions in stratified squamous epithelia and disruption of desmosomal adhesion has been shown to have dramatic effects on the function and integrity of these tissues. During normal physiologic processes, such as tissue development and wound healing, intercellular adhesion must be modified locally to allow coordinated cell movements. The mechanisms t...
متن کاملDefining desmosomal plakophilin-3 interactions
Plakophilin 3 (PKP3) is a recently described armadillo protein of the desmosomal plaque, which is synthesized in simple and stratified epithelia. We investigated the localization pattern of endogenous and exogenous PKP3 and fragments thereof. The desmosomal binding properties of PKP3 were determined using yeast two-hybrid, coimmunoprecipitation and colocalization experiments. To this end, novel...
متن کاملThe Desmosomal Plaque Proteins of the Plakophilin Family
Three related proteins of the plakophilin family (PKP1_3) have been identified as junctional proteins that are essential for the formation and stabilization of desmosomal cell contacts. Failure of PKP expression can have fatal effects on desmosomal adhesion, leading to abnormal tissue and organ development. Thus, loss of functional PKP 1 in humans leads to ectodermal dysplasia/skin fragility (E...
متن کاملThe 14-3-3 proteins
So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...
متن کاملCorrection for “ 14 - 3 - 3 σ regulates B - cell homeostasis through stabilization of FOXO 1
IMMUNOLOGY Correction for “14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1,” by Yu-Wen Su, Zhenyue Hao, Atsushi Hirao, Kazuo Yamamoto, Wen-Jye Lin, Ashley Young, Gordon S. Duncan, Hiroki Yoshida, Andrew Wakeham, Philipp A. Lang, Kiichi Murakami, Pamela Ohashi, and Tak W. Mak, which appeared in issue 4, January 25, 2011, of Proc Natl Acad Sci USA (108:1555–1560; first publish...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0077012